Defy Medical provides hormone restoration to patients who are struggling from hormone imbalance. On the other hand, patients who don’t experience skin irritation may like the consistency and faster rate of absorption found in gels. For example, cream-based delivery systems apply better to skin in sensitive areas, such as the scrotum or inner thighs. Men typically require 7 mg to 10 mg of Testosterone absorbed per day to optimize hormone levels. Similar to a smoking cessation patch, these patches stay on your skin throughout the day and deliver the medication over time. The lighter formula works well when delivering one medication, while the heavy base work well for multiple hormones/medications. This base typically works well for patients who like the benefits of lotion along with their topical hormone dose. The only additional entry criterion was providing written consent to complete the study. The randomization code envelope was opened after a participant consented to enter the study. Randomization was achieved by participants being issued sequential, unique (never reused) study identification numbers with the computer-generated randomization code supplied in opaque sealed envelopes marked on the outside by the study identification. The drug was supplied by the Concord Hospital pharmacy within the national health scheme. The study was conducted in an ambulatory clinic of an academic andrology center (Andrology Department, Concord Hospital) between 2014 and 2018 without external funding. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. This medication is given by injection into the buttock muscle as directed by your doctor, usually every 1 to 4 weeks. Versabase® is a transdermal cream that also has cosmetic and moisturizing effects. This naturally mimics the rise and fall of Testosterone levels throughout the day. Typically, a small amount of the applied hormone reaches the blood, so dosages are created with this in mind.